Synthesis of phenylacetaldehyde amidines and their intramolecular cyclization
نویسندگان
چکیده
منابع مشابه
Synthesis of Heterocycles by Intramolecular Cyclization of Organic Azides
A review of synthetic methodologies reported in the last five years that yield N-heterocyclic products by intramolecular cyclization of organic azides with a particular emphasis on transformations catalyzed by metal complexes is presented. These reactions have been classified according to the ring size of the formed heterocycle.
متن کاملLactone-directed intramolecular Diels-Alder cyclization: synthesis of trans-dihydroconfertifolin.
Trienes 1 and 3 were obtained in five steps from ethyl 4-acetoxy-3-oxobutanoate and 6-iodo-3-methyl-1,3-hexadiene. Intramolecular Diels-Alder cyclization of 1 and 3 gave tricyclic lactones 2 and 4 as the major products, respectively. The key intermediate 4 was converted in two steps to trans-dihydroconfertifolin (5).
متن کاملIntramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids.
Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is ...
متن کاملExcited-State Parameters of One Intramolecular Cyclization by TD-DFT, CIS and ZINDO Methods
Using a time-dependent-density functional theory (TD-DFT), Configuration Interaction Singles (CIS) and Zerner’s Intermediate Neglect of Differential Overlap (ZINDO) methods, we have investigated the UV-Visible spectra of one new intramolecular cyclization at before and after intramolecular attack. All structures were optimized at the B3LYP/6-311++G** level while UV-Visible parameters were calcul...
متن کاملCopper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines.
An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arkivoc
سال: 2008
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0009.c16